Keywords
atomic force microscopy
mechanical testing
interdiciplinary applicability
workflow
How to Cite
Abstract
Atomic force microscopy is used for characterization of biological samples, individual molecules, molecular interaction and their roles in friction and adhesion at molecular and cellular levels. The current paper aims to summarize the atomic force microscopy, its working principle, the usage of it in characterization of bone and latest developments appeared. The proposed workflow for the AFM is developed based on current observations based on articles studied in current paper and their results, their limitations and remained gaps to be solved, as well as there are also additional steps shown for educational purposes. Potential bias in elastic modulus and boundary condition errors, variability of values and lack of standardization plus possible bias sources, biases in algorithm are the limitations and problems needed to be still solved. Therefore, a combined effort of specialists in biomechanics, tissue engineering and biomaterials is necessary to be conducted further.
References
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