Application of mass spectrometry for imaging the distribution of primary and secondary metabolites in the storage root of red radish
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Keywords

radish, Raphanus sativus, mass spectrometry imaging, silver nanoparticles, low molecular weight metabolites

Abstract

The radish (Raphanus sativus L.) is one of the most widely cultivated vegetables in the world, as it is rich in a variety of metabolites essential for human nutrition and health. The distribution of low molecular weight metabolites, including amino acids, sugars, fatty acids, sterol, organic acids, vitamins, gibberellins, glucosinolates and their breakdown products, phenols, and flavonoids, within the cross-sections of small red radish storage root  was investigated using mass spectrometry imaging (MSI) method with 109Ag nanoparticticle enhanced target (109AgNPET). The biological functions and health-promoting roles of the compounds studied are also discussed.

https://doi.org/10.7862/rc.2025.2
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References

Nishio, T., Economic and academic importance of radish, in: Nishio, T., Kitashiba, H. (Eds.), The Radish Genome, Springer, Cham, 2017, pp.1-10.

Khattak, K.F., Pak. J. Pharm. Sci., 24, 277-283 (2011).

Singh, A., Sharma, S., Dolly, Radish, in: Nayik, G.A., Gull, A. (Eds.), Antioxidants in Vegetables and Nuts – Properties and Health Benefits, Springer, 2020, pp. 209-235.

Gamba, M., Asllanaj, E., Raguindin, P.F., Glisic, M., Franco, O.H., Minder, B., Bussler, W., Metzger, B., Kern, H., Muka, T., Trends Food Sci. Technol., 113, 205-218 (2021).

Seaman, C., Flinders, B., Eijkel, G., Heeren, R.M.A., Bricklebank, N., Malcolm, R., Clench, M.R., Anal. Chem., 86, 10071-10077 (2014).

Brauer, J.I., Beech, I.B., Sunner, J., J. Am. Soc. Mass Spectrom., 26, 1538-1547 (2015).

Ondrasek, G., Rengel, Z., Clode, P.L., Kilburn, M.R., Guagliardo, P., Romic, D., Ecotoxicol. Environ. Saf., 171, 571-578 (2019).

Zuo, Y., Zhang, W., J. Hazard. Mater. Lett., 6, 100141 (2025).

Nizioł, J., Rode, W., Laskowska, B., Ruman, T., Anal. Chem., 85, 1926-1931 (2013).

Zaki, H.E.M., Takahata, Y., Yokoi, S., J. Hortic. Sci. Biotech., 87, 172 (2012).

Bell, L., Oloyede, O.O., Lignou, S., Wagstaff, C., Methven, L., Mol. Nutr. Food Res., 62, e1700990 (2018).

Kim, J.K., Bong, S.J., Park, S.U., Asian J. Chem., 29, 1427-1430 (2017).

Béres, T., Štefelová, N., Ćavar Zeljković, S., Kopecký, P., Foods, 12, 2823 (2023).

Kendziorek, M., Paszkowski, A., Zagdanska, B., Plant Cell Rep., 31, 1105-1117 (2012).

Ponrasu, T., Jamuna, S., Mathew, A., Madhukumar, K.N., Ganeshkumar, M., Iyappan, K., Suguna, L., Amino Acids, 45, 179-189 (2013).

Park, C.H., Ki, W., Kim, N.S., Park, S.-Y., Kim, J.K., Park, S.U., Horticulturae, 8, 310 (2022).

Li, R., Zhu, Y., J. Sci. Food Agric., 98, 5853-5860 (2018).

Kobayashi, W., Kobayashi, T., Takahashi, A., Kumakura, K., Matsuoka, H., J. Food Sci., 86, 563-570 (2021).

Amir, R., Amino Acids, 39, 917-931 (2010).

Lea, P.J., Sodek, L., Parry, M.A.J., Shewry, P.R., Halford, N.G., Ann. Appl. Biol., 150, 1-26 (2007).

Ros, R., Muñoz-Bertomeu, J., Krueger, S., Trends Plant Sci., 19, 564-569 (2014).

Li, X., Liu, D., Front. Nutr., 9, 840641 (2022).

Lee, K.-T., Liao, H.-S., Hsieh, M.-H., Plant Cell Physiol., 64, 1466-1481 (2023).

Schiavon, M., Berto, C., Malagoli, M., Trentin, A., Sambo, P., Dall'Acqua, S., Pilon-Smits, E.A.H., Front. Plant Sci., 7, 1371 (2016).

Yoo, H., Widhalm, J., Qian, Y., Maeda, H., Cooper, B.R., Jannasch, A.S., Gonda, W., Lewinsohn, E., Rhodes, D., Dudareva, N., Nat. Commun., 4, 2833 (2013).

Park, C.H., Park, S.Y., Park, Y.J., Kim, J.K., Park, S.U., J. Agric. Food Chem., 68, 13711-13719 (2020).

Radwanski, E.R., Last, R.L., Plant Cell, 7, 921-934 (1995).

Frankenberger, W.T. Jr., Chang, A.C., Arshad, M., Plant Soil, 129, 235-241 (1990).

Schenck, C.A., Maeda, H.A., Phytochemistry, 149, 82-102 (2018).

El-Beltagi, H.S., Maraei, R.W., Shalaby, T.A., Aly, A.A., Agronomy, 12, 1916 (2022).

Hara, M., Torazawa, D., Asai, T., Takahashi, I., Int. J. Food Sci. Tech., 46, 2387-2392 (2011).

Neurath, G.B., Dünger, M., Pein, F.G., Ambrosius, D., Schreiber, O., Food Cosmet. Toxicol., 15, 275-282 (1977).

Schäfer, J., Brett, A., Trierweiler, B., Bunzel, M., J. Agric. Food Chem., 64, 8625-8632 (2016).

Upchurch, R.G., Biotechnol. Lett., 30, 967-977 (2008).

Huang, C.B., Ebersole, J.L., Mol. Oral Microbiol., 25, 75-80 (2010).

Ragasa, C.Y., Ng, V.A.S., Torres, O.B., Sevilla, N.S. Y., Uy, K.V.M. , Tan, Ma.C.S., Noel, M.G., Shen, C.-C., J. Chem. Pharm. Res., 5, 1237-1243 (2013).

Kachroo, P., Shanklin, J., Shah, J., Whittle, E.J., Klessig, D.F., Proc Natl Acad Sci USA, 98, 9448-9453 (2001).

Selyutina, G., Gapontseva, O., Ukr. Food J., 5, 653-666 (2016).

Blažević, I., Mastelić, J., Food Chem., 113, 96-102 (2009).

Pérez Gutiérrez, R.M., Perez, R.L., Sci. World J., 4, 811-837 (2004).

Eveline, Pasau R.C., IOP Conf. Ser.: Earth Environ. Sci., 292, 012036 (2019).

Yusuf, E., Tkacz, K., Turkiewicz, I.P., Wojdyło, A., Nowicka, P., Eur. Food Res. Technol., 247, 3053-3062 (2021).

Cai, X., Zhu, K., Li, W., Peng Y., Yi Y., Qiao, M., Fu Y., Food Chem., 22, 101419 (2024).

Bae, R., Lee, Y.-K., Lee, S.-K., Kor. J. Hort. Sci. Technol., 30, 409-416 (2012).

Schlering, C., Dietrich, H., Frisch, M., Schreiner, M., Schweiggert, R., Will, F., Zinkernagel, J., J. Appl. Bot. Food Qual., 92, 343-354 (2019).

Mei, S., He, Z., Zhang, J., Front. Nutr., 9, 889407 (2022).

Fitzpatrick, T.B., Chapman, L.M., J. Biol. Chem., 295, 12002-12013 (2020).

Boubakri, H., Gargouri, M., Mliki, A., Brini, F., Chong, J., Jbara, M., Planta, 244, 529-543 (2016).

Kwiatkowska, C.A., Finglas, P.M., Faulks R.M., J. Hum. Nutr. Diet., 2, 159-172 (1989).

Zieliński, H., Frias, J., Piskuła, M.K., Kozłowska, H., Vidal-Valverde, C., Eur. Food Res. Technol., 221, 78-83 (2005).

Khattak, K.F., Rahman, T.U., Int. Food Res. J., 24, 292-297 (2017).

Maria, C.A.B., Moreira, R.F.A., Quim Nova, 34, 1739-1752 (2011).

Kumakura, K., Kato, R., Kobayashi, T., Sekiguchi, A., Kimura, N., Takahashi, H., Takahashi, A., Matsuoka, H., Food Chem., 231, 33-41 (2017).

Webb, M., Smith, A., Adv. Bot. Res., 58, 203-255 (2011).

Fitzpatrick, T.B., Adv. Bot. Res., 59, 1-38 (2011).

Choi, S.-R., Song, Y.-E., Han, H.-A., Lee, S.-Y., Shin, S.-H., Park. J.-J. Korean J. Food Nutr., 32, 745-752 (2019).

Francis, H., Debs, E., Koubaa, M., Alrayess, Z., Maroun, RG, Louka, N., Foods, 11, 1460 (2022).

van Oostende, C., Widhalm, J.R., Furt , F., Ducluzeau, A.-L., Basset, G.J., Adv. Bot. Res., 59, 229-261 (2011).

Mladěnka, P., Macáková, K., Kujovská Krčmová, L., Javorská, L., Mrštná, K., Carazo, A., Protti, M., Remião, F., Nováková, L., Nutr. Rev., 80, 677-698 (2022).

Damon, M., Zhang, N.Z., Haytowitz, D.B., Booth, S.L., J. Food Comp. Anal., 18, 751-758 (2005).

Achard, P., Gusti, A., Cheminant, S., Alioua, M., Dhondt, S., Coppens, F., Beemster, G.T., Genschik, P., Curr. Biol., 19, 1188-1193 (2009).

Colebrook, E.H., Thomas, S.G., Phillips, A.L., Hedden, P., J. Exp. Biol., 217, 67-75 (2014).

Nakayama, M., Yamane, H., Yokota, T., Yamaguchi, I., Murofushi, N., Takahashi, N., Nishijima, T., Katsura, N., Nonaka, M., Gaskin, P., MacMillan, J., Mander, L.N., Chu, A., Agric. Biol. Chem., 54, 837 (1990).

Koshioka, M., Nishijima, T., Yamazaki, H., Mander, L.N., Phytochemistry, 38, 359-363 (1995).

Kakizaki, T., Ishida, M., Genetic profile of glucosinolate biosynthesis, in: Nishio, T., Kitashiba, H. (Eds.), The Radish Genome, Springer, Cham, 2017, pp. 137-150.

Wu, X., Sun, J., Haytowitz, D.B., Harnly, J.M., Chen, P., Pehrsson, P.R., J. Food Comp. Anal., 64, 78-84 (2017).

Björkman, M., Klingen, I., Birch, A.N.E., Bones, A. M., Bruce, T.J.A., Johansen, T.J., Meadow, R., Mølmann, J., Seljåsen, R., Smart, L.E., Stewart, D., Phytochemistry, 72, 538-556 (2011).

Kim, S.-J., Uddin, M.R., Park, S.U., Australian J. Crop. Sci., 7, 1843-1847 (2013).

Grubb, C.D., Abel, S., Trends Plant Sci., 11, 89-100 (2006).

Traka, M.H., Melchini, A., Mithen, R.F., Drug Discov. Today, 19, 1488-1492 (2014).

Chen, W., Wang, Y., Liang Xu, Dong, J., Zhu,X., Ying, J., Wang, Q., Fan, L., Li, C., Liu, L., Scientia Hort., 250, 159-167 (2019).

Kim, J.W., Kim, M.B., Lim, S.B., Prev. Nutr. Food Sci., 20, 119-125 (2015).

Aissani, N., Sebai, H., Food Prop., 25, 1934-1947 (2022).

Dinh, T.N., Parat, M.-O., Ong, Y.S., Khaw, K.Y., Pharmacol. Res., 16, 105666 (2021).

Suh, S.-J., Moon, S.-K., Kim, C.-H., Int. Immunopharmacol., 6, 854-861 (2006).

Po, W.W., Choi, W.S., Khing, T.M., Lee, J.-Y., Lee, J.H., Bang, J.S., Min, Y.S., Jeong, J.H., Sohn, U.D., Biomol. Ther., 30, 348-359 (2022).

Nakamura, Y., Nakamura, K., Asai, Y., Wada, T., Tanaka, K., Matsuo, T., Okamoto, S., Meijer, J., Kitamura, Y., Nishikawa, A., Park, E.Y., Sato, K., Ohtsuki, K., J. Agric. Food Chem., 56, 2702-2707 (2008).

Liu, Y., Zhang, H., Umashankar, S., Liang, X., Lee, H., Swarup, S., Ong, C., Metabolites, 8, 94 (2018).

Nakamura, Y., Iwahashi T., Tanaka, A., Koutani, J., Matsuo, T., Okamoto, S., Sato, K., Ohtsuki, K., J. Agric. Food Chem., 49, 5755-5760 (2001).

Ampofo, E., Schmitt, B.M., Menger, M.D., Laschke, M.W., Mini Rev. Med. Chem., 18, 962-968 (2018).

Williams, D.E., Front. Nutr., 8, 7343342021 (2021).

Ramirez, D., Beretta, V., Torres-Palazzolo, C., Camargo, A.B., Food Saf. Health, 1, 93-101 (2023).

Goyeneche, R., Roura, S., Ponce, A., Vega-Gálvez, A., Quispe-Fuentes, I., Uribe, E., Di Scala, K., J. Funct. Foods, 16, 256-264 (2015).

Duthie, G.G., Duthie, S.J., Kyle, J.A.M., Nurt. Res. Rev., 13, 79-106 (2000).

Koley, T.K., Khan, Z., Oulkar, D., B.K. Singh, Maurya, A., Singh, B., Banerjee, K., Arab. J. Chem., 13, 1355-1366 (2020).

Fusari, C.M., Nazareno, M.A., Locatelli, D.A., Fontana, A., Beretta, V., Camargo, A.B., Food Biosci., 36, 100606 (2020).

Liu, T., Liu, T., Zhang, X., Song, J., Qiu, Y., Yang, W., Jia, H., Wang, H., Li, X., Plant Physiol. Biochem., 195, 351-361 (2023).

Jing, P., Song, L.-H., Shen, S.-Q., Zhao, S.-J., Pang, J., Qian, B.-J., Molecules, 19, 9675-9688 (2014).

Mattila, P., Hellström, J., J. Food Compost. Anal., 20, 152-160 (2007).

Giusti, M.M., Wrolstad, R.E., Biochem. Eng. J., 14, 217-225 (2003).

Wang, L.S., Sun, X.D., Cao, Y., Wang, L., Li, F.J., Wang, Y.F., Food Chem. Toxicol., 48, 2712-2718 (2010).

Khoo, H.E., Azlan, A., Tang, S.T., Lim, S.M., Food Nutr. Res., 61, 1361779 (2017).

Jing, P., Zhao, S.-J., Ruan, S.-Y., Xie, Z.-H., Dong, Y., Yu, L.(L), Food Chem., 133, 1569-1576 (2012).

Park, C.H., Baskar, T.B., Park, S.-Y., Kim, S.-J., Valan Arasu, M., Al-Dhabi, N.A., Kim, J.K., Park, S.U., Molecules, 21, 157 (2016).

Park, N.I., Xu, H., Li, X., Jang,I.H., Park, S., Ahn, G.H., Lim, Y.P., Kim, S.J., Park, S.U., J. Agric. Food Chem., 59, 6034-6039 (2011).

Bilyk, A., Sapers, G.M., J. Agric. Food Chem., 33, 226-228 (1985).

Miean, K.H., Mohamed, S., J. Agric. Food Chem., 49, 3106-3112 (2001).

Beevi, S.S., Narasu, M.L., Gowda, B.B., Plant Foods Hum. Nutr., 65, 8-17 (2010).

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